The primary objective of the trial is to test safety and to identify the recommended Phase 2 dosing. The secondary objectives are to test tumor marker Kinetics measured in the blood via standard assays; PSA, CA-125, CEA, etc. We added exploratory objectives to monitor the growth of cancer as measuring by cat scan, bone scan, or other imaging modality that was being used to monitor the patient’s cancer. 

“We also wanted to explore potential targets, biomarkers, predictors in PBMCs (peripheral blood mononuclear cells), to access tumor burden dynamics through serum and plasma, to evaluate germ-line mutations in circulating DNA, and to see changes in cytokine productions in PBMCs.
Patient eligibility criteria requires that a patient be a solid tumor patient, stage IV, that at least one line of prior systemic therapy or other standard treatment, and have a life expectancy of greater than three months. 

A standard 3 + 3 design was used where three patients in the trial are assigned to a dose level in order of the study entry until a subject experiences a drug-related toxicity of a grade two or higher, whereupon an additional three patients will be enrolled at that dose level.”

To date Dr. Paller has consented 15 patients into the trial and is expecting 16-22 more! The trial is progressing well and will take another 2 years to complete because the FDA has required us to follow-up with a patient for 28 days after their initial dose.

Thank you for partnering with us to make this trial possible!

To learn more about who is eligible to participate, please email: phase1trials@jhmi.edu . You can also call  410-502-5140 .

Brad was diagnosed in February of 2018. In July, he spent 35 days getting two surgeries and spent the fall recovering before his last surgery on December 14th.

This week, he went home for the first time in 10 months where the doctors have said that there is no evidence of disease.

Brad attributes his Christmas miracle to the power of prayer, clinical medicine, complementary medicine that includes mistletoe therapy and nutrition therapy, and incredible support from family and friends. His sister, Stacy, shared that she doesn’t need another gift….ever.”

Watch the video here >

Hello. I’m honored to be here tonight and share with you the hope I’ve been given in the face of cancer. At this very moment, I am fighting cancer. Three years ago, I was diagnosed with triple negative breast cancer. I was 35 years old, married to my husband, Ken, and our girls Sam and Layla, were 5 and 3. The news was devastating. It was also baffling. Breast cancer doesn’t run in my family.

And, I was on a health kick and feeling my best when the tumor showed up. Now, “Triple Negative breast cancer” sounds bad, and it is. It is more aggressive in women under 40 and is more difficult to treat than other types of breast cancer. In fact, out of all breast cancers, mine has the lowest 5-year survival rate, of only 14%. To top that off, my first oncologist informed me that conventional cancer treatments would “guarantee a second cancer.” Seven surgeries and three years later, I’m here tonight to celebrate the light that Believe Big has brought into our lives. Believe Big has been steadfast, never giving up on me and giving me plenty of practical help.

They awarded me a wellness grant for IV mistletoe therapy, a house cleaning coupon, a treasured book at Christmastime, and my “fav” a Believe Big mug with the I Will Have No Fear prayer card. I see and read it EVERYDAY, multiple times a day. I use my mug first thing in the morning and last thing before bed to remind me of the gift of hope when I am feeling my worst. I receive amazing support and information from Believe Big at no cost. Believe Big told me about mistletoe, directed me to a physician who could prescribe it, and connected me to a health center with an integrative approach to treat my individual “terrain”.

To this day, I refer to the Believe Big website almost weekly. The “first steps” section was like gold to me when I was newly-diagnosed, emotional and needed someone to tell me what to do next. The website’s comprehensive list of mistletoe doctors state by state is invaluable, along with healthy recipes, ways to navigate safer foods and products, and other tools that launched me into my research journey. I now have a retreat-like in-home studio for the non-toxic therapies that elevate my health and well-being.

My individualized diet and supplements, light exercise, juicing, meditation, on-going mistletoe therapy, and Acupuncture all started with my call to Believe Big. I “Believe Big” and maintain a positive attitude every day. I’ve followed this protocol without conventional treatments and it is working. I stand here today not in full remission, but full of hope. Soon after my diagnosis, I attended the Believe Big Dinner and heard inspiring stories of how to integrate treatments, giving me a big dose of confidence that I could do it, too. I am doing it!

Believe Big teaches how to live with cancer. Believe Big teaches us how to THRIVE with cancer. That’s what I am doing here. I don’t want to die from cancer. I want to live with cancer. I’m convinced that telling our stories is truly a cathartic part of the healing process.

Thank you Believe Big for this night and for the opportunity to speak and to fulfill my purpose, my dream….to be a Hope Giver like you.

Contemporary Ceramic Studios Association (CCSA) Wraps Up 2017 Annual Convention and Raises Over $28,000 for Believe Big

The convention brought together hundreds of PYOP studio owners, as well as several exhibitors who serve the PYOP marketplace. It also featured nearly 60 classes on topics such as business development, art techniques and more.

The Contemporary Ceramic Studios Association (CCSA), a not-for-profit trade association serving the needs of ceramic and paint your own pottery (PYOP) studios and suppliers worldwide, has wrapped up its 2017 annual convention and raised $28,417 for charity.

The convention, which took place from August 25-28 at the Kierland Westin hotel in Scottsdale, Arizona, brought together hundreds of PYOP studio owners, as well as several exhibitors who serve the PYOP marketplace. It also featured nearly 60 classes on topics such as business development, art techniques and more.

Per tradition, the CCSA also took the opportunity at its annual convention to raise funds for a charity that was selected by the association’s board, from recommendations submitted by CCSA members. This year’s beneficiary of a fundraising gala that included an auction, raffle and live band and dancing was Believe Big, a not-for-profit organization founded by Ivelisse and Jimmy Page. Established in 2011, after Ivelisse’s battle with Stage IV colon cancer, Believe Big’s mission is to bridge the gap between conventional and complementary medicine for fighting cancer, and provide patients with hope, help and healing.

“Each year when our annual convention ends, I tell myself that it can’t possibly get any better — but it always does!” commented CCSA executive director Dena Pearlman. “I’m grateful to everyone who made this our best convention ever, and I’m especially proud of our members who once again stepped up and raised funds for an important and inspiring cause.”

“Our annual convention is the premier event for contemporary ceramic studios,” commented CCSA board president Wendy Pettys. “It was four great days of networking, education, and of course, the amazing fundraising gala.”

The CCSA’s 2018 annual convention will be held next September 14-17 in St. Charles, Missouri. Additional details including hotel information and online registration will be published on the CCSA’s in spring 2018.

For additional information, including inquiries about launching a CCSA-member PYOP studio, contact Dena Pearlman at (888) 291-2272 or dena(at)ccsaonline.com.

About the Contemporary Ceramic Studios Association

The Contemporary Ceramic Studios Association (CCSA) is a not-for-profit trade association serving the needs of ceramic and paint your own pottery studios and suppliers around the world. The Mission of the CCSA is to promote creativity and excitement about our industry and be a resource for our members. Whether you’re a seasoned studio owner or someone who is thinking about opening your own Paint Your Own Pottery studio, this is the place to be.

Learn more at http://www.ccsaonline.com. Facebook users can also follow the CCSA at https://www.facebook.com/ccsapaintyourownpottery, or connect with PYOP fans across the world at https://www.facebook.com/Paint-Your-Own-Pottery-206166622756971/.

Original article:
http://www.prweb.com/releases/ccsa/paint-your-own-pottery/prweb14638370.htm